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amino benzo f chromene grinding method

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A Greener Synthesis of 2-Aminochromenes in Ionic Liquid ,

Abstract: An improved simple and facile synthesis of chromene derivatives by employing three-component one-pot condensation reaction of β-naphthol, aromatic aldehydes, and malononitrile in ionic liquids is described The ionic liquid can be reused and recycled The chromene derivatives were..

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A simple and fast protocol for the synthesis of 2-amino-4 ,

In this study, a novel optical immunoassay platform was developed by using an optical probe 2-amino-4-(4-formylphenyl)-4H-chromene-3-carbonitrile (AFC), which was synthesized via greener Ultra-sonication method The structure of the probe was elucidated through Fourier-Transform Infrared Spectroscopy and Nuclear Magnetic Resonance spectroscopy techniqu..

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Silica bonded n-propyl-4-aza-1-azoniabicyclo[222]octane ,

Jul 31, 2011· Highlights Introducing a new catalyst for organic transformations Introducing an efficient new method for synthesis of 2-amino-4H-benzo[b]pyrans Superiority of the catalyst in comparison with the reported catalysts Generality and simplicity of the method, high yields and short reaction tim Environmental compatibility, non-toxicity, low cost and recoverability of the catalyst..

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A facile and green three-component synthesis of 2-amino-3 ,

A simple, e cient and one-pot method has been developed for the synthesis of densely functionalized aryl derivatives of 2-amino-3-cyano-7-hydroxy-4H-chromene by the domino Knoevenagel-Michael-cyclization reactions of aromatic aldehydes, resorcinol and malononitrile in the presence of a catalytic amount of Na2CO3 under grinding conditions..

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Diastereodivergent Synthesis of Hexahydro-6H-benzo[c ,

interest latterly, and several organocatalytic methods have been developed for the efficient assembly of such tricyclic skeleton[4] However, to our knowledge, there is no method that can achieve the catalytic diastereodivergent synthesis of hexahydro -6H benzo[c]chromene derivativ Figure 1..

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Efficient Synthesis of Benzo[g]- and Benzo[h]chromene ,

A highly efficient and straightforward one-pot three-component synthesis of functionalized 2-amino-4H-chromenes and indole-substituted 3-amino-1H-benzo[f]chromenes have been developed by 3-amino ,..

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New conversion of Friendländer reaction of 3-amino-1H ,

Jan 01, 2008· The required 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitriles 1 for this approach, were conveniently synthesized by the three-component reaction of commercially available aldehydes, naphthol and malononitrile in a standard methodology reported by Wen et al and Kidwai et al ()The cyclocondensation of 1 with cyclohexanone 2 in DMF in the presence of anhydrous zinc chloride ,..

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7-Methoxy-2-naphthol 98% | 5060-82-2

7-Methoxy-2-naphthol may be used in the synthesis of new 1H-benzo[f]chromene derivativIt may be used in the synthesis of 7-methoxy-2-naphthyl (MN)-derived xylosides in which the methoxy group served as a marker for NMR characterization and UV detection..

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Synthesis of ethyl-3-amino-1-aryl-1H-benzo[f]chromeme-2 ,

new method for the synthesis of chromene derivatives using DMAP as catalyst and co-solvent (additive), as a rapid convenient method with suitable yields The point is which lead to higher purity , Ethyl 3-amino-1-p-tolyl-1H-benzo[f]chromene-2-carboxylate (5f)..

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3-Amino-1-(4-fluoro-phen-yl)-8-meth-oxy-1H-benzo[f ,

Mar 02, 2013· The title compound, C 21 H 15 FN 2 O 2, features an approximately planar 1H-benzo[f]chromene fused-ring system (rms deviation for the 14 non-H atoms = 0052 Å), with the fluoro­benzene ring being almost perpendicular to this [dihedral angle = 8530 (7) °]The furan ring has a flattened half-chair conformation, with the methine C atom deviating by 0132 (2) Å from the plane of ,..

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Synthesis, antitumor activity of 2-amino-4H-benzo[h ,

Based on the reported cytotoxic activity of a great number of bioactive compounds incorporating chromene or benzochromene moieties, 3-amino-1-aryl-1H-benzo[f] chromene-2 ,..

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Potassium phthalimide-N-oxyl: a novel, efficient, and ,

Jan 21, 2013· A wide variety of 2-amino-4H-chromene derivatives with diverse substituents on the 4H-chromene ring were efficiently prepared via one-pot, three-component reaction of an aromatic aldehyde, malononitrile (or ethyl cyanoacetate), and diverse enolizable C–H activated acidic compounds in the presence of low loading of potassium phthalimide-N-oxyl (POPINO), as a new organocatalyst, in ,..

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Crystal Structure of 2-amino-4-(4-hydroxyphenyl)-5, 10 ,

4H-benzo[g] chromene-3-carbonitrile D K Sharma1, A Jayashree2, B Narayana2, B K Sarojini3, , methods and refined by full-matrix least squares procedures to a final R value of 01199 for 2629 observed , (for C12 atom of the chromene ring system) The amino and cyanide groups attached at ,..

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Convenient and Efficient One-Pot Method for the Synthesis ,

Jun 05, 2012· A convenient and efficient one-pot method for the synthesis of 2-amino-tetrahydro-4H-chromene and 2-amino-4H-benzo[h]-chromene derivatives has been developed using a catalytic amount of amino-functionalized MCM-41 in aqueous mediumThis efficient technique has the advantages of giving 4H-tetrahydro-chromene and 4H-benzo[h]chromene building blocks using a reusable ,..

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Synthesis of 2-amino-4H-chromene derivatives under ,

ing method to construct the 2-amino-4H-chromene skeleton 2 Experimental 21 Materials and methods Solvents used were of analytical grade All melt-ing points were taken in open capillaries and are uncorrected Thin-layer chromatography (TLC, on alu-minium plates precoated with silica gel, 60F254, 025mm thickness) (Merck, Darmstadt, Germany) was..

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DIGITALCSIC: The reaction of 2-amino-4 H-pyrans with N ,

The reaction of racemic 2-amino-4H-pyrans, such as 3-amino-1-aryl-1H-benzo[f]chromene-2-carbonitriles, with N-bromosuccinimide (NBS), in CH2 Cl2, at room temperature, is a very quick, regio, stereoselective, and high yielding process, affording major racemic (1S,2S)-2-bromo-3-imino-benzo[f]chromene or racemic (1S,2S)-2-bromo-3-(bromoimino ...

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Preparation and Characterization of a Molybdenum(VI ,

method of synthesis For the synthesis of 2-amino-4H-benzo[h]chromenes, different methods were reported [41-44] Although these methods are efficient, but many of them require expensive catalyst, difficult workup and toxic organic solvents [45-48] Therefore, considering the pharmacologically and biologically importance of chromenes, attempt..

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Clean chemical synthesis of 2-amino-chromenes in water ,

All synthesized products were characterized by spectroscopic methods including 1H NMR, 13C, IR and EI mass spectrometry, as well as by their melting points 2-1 Characterization of 2-amino-2-chromenes 4 2-Amino-3-cyano-4-phenyl-4H-benzo[h]chromene (4a): Yellow solid, mp = 207-210°C 1H NMR (CDCl3, 300 MHz) δ en ppm : 4,79 (2H, s, NH2)..

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Solvent-free synthesis of 1-amidoalkyl-2-naphthol and 3 ,

A green procedure for the one-pot three-component synthesis of 1-amidoalkyl-2-naphthol and 3-amino-1-phenyl-1H benzo[f]chromene-2-carbonitrile derivatives from the reaction of 2-naphtol, aldehydes, and malononitrile/acetamide in the presence of a catalytic amount of Fe 3 O 4 @enamine-B(OSO 3 H) 2 as an efficient and novel heterogeneous magnetic nanostructure catalyst is described..

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1 Introduction - Hindawi

In the last decade numerous methods have been developed for the synthesis of 4 H-benzo[b] , pyrazole derivatives by a grinding method under solvent-free conditions Synthetic , and simple organocatalyst for the one-pot three-component synthesis of various 2-amino-4H-chromene derivatives in water Tetrahedron 2013 69 3 1074 1085 101016/jtet ...

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Synthesis of (±)‐cis‐1‐Aryl‐3‐oxo‐2,3‐dihydro‐1H‐benzo[f ,

Nov 27, 2019· The unexpected stereospecific synthesis of (±)-cis-1-aryl-3-oxo-2,3-dihydro-1H-benzo[f]chromene-2-carbonitriles (2) and (±)-trans-4-aryl-2-oxo-3,4-dihydro-2H-benzo[h]chromene-3-carbonitriles (4) from (±)-3-amino-1-aryl-1H-benzo[f]chromene-2-carbonitriles (1) and (±)-2-amino-4-aryl-4H-benzo[h]chromene-3-carbonitriles (3), respectively, by ...

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4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis ,

Background: A series of 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives were synthesized and evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lin Methods: The one-pot, three-component reaction of α or β-naphthol, malonitrile and an aromatic aldehyde in the presence of diammonium hydrogen phosphate was afforded the ...

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The One-Step Synthesis of 3,4-Dihydropyrano[F]Chromene ,

Table 1: 3-amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile 4a–g in under grinding using DABCO Yields refer to pure isolated products characterized b y IR, 1 H and 13 C N MR spectroscopy and mass spectrometry The structures of compounds 4 were deduced from their 1 H NMR, 13 C NMR and IR spectral data and their molecular weight confirmed by mass spectrometry..

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Novel One-Pot Three- and Pseudo-Five-Component Reactions ,

A novel and efficient method has been developed for the synthesis of highly functionalized benzo[g]- and dihydropyrano[2,3-g]chromene derivatives via addition and subsequently cyclization of 2-hydroxynaphthalene-1,4-dione or 2,5-dihydroxycyclohexa-2,5-diene-1,4-dione to the condensation product of an aldehyde with malononitrile in the presence of a catalytic amount of Et3N in CH3CN at ,..

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X-ray, Microwave Assisted Synthesis and Spectral Data of 3 ,

A convenient and efficient method using Microwave assisted synthesis of 3-amino-1-(3,5-di-bromo-2-methoxyphenyl-8-methoxy-1H-benzo[f]chromene-2-carbonitrile 5, via reaction of 6-methoxy-2-naphthol 1 with a mixture of 3,5-dibromo-2-methoxybenzaldehyde 2 and malononitrile 3 and also, by the reaction of 6-methoxy-2-naphthol 1 with 2-(3,5-dibromo-2-methoxybenzylidene)-malononitrile 4 in ethanolic ...

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3-Amino-1-(2-ethoxyphenyl)-1H-benzo[f]chromene-2 ,

Structure, properties, spectra, suppliers and links for: 3-Amino-1-(2-ethoxyphenyl)-1H-benzo[f]chromene-2-carbonitrile Jump to main content Jump to site nav Home..

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- Personal page - دانشگاه گیلان

An affordable DABCO-based ionic liquid efficiency in the synthesis of 3-amino-1-aryl-1H-benzo[f] chromene-2- carbonitrile, 1-(benzothiazolylamino)phenylmethyl-2-naphthol, and 1-(benzoimidazolylamino)phenylmethyl-2-naphthol derivatives ,Journal of ,..

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Synthesis, Characterization, Biological Activity of Novel ,

Background: Chromene, benzochromene and their derivatives have been considered as an important class of oxygen-containing heterocycl There has been incr...

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2-Amino-4-(4-bromo­phen­yl)-6-meth­oxy-4H-benzo[h]chromene ,

Apr 01, 2013· Nevertheless, the 14 non-hydrogen atoms comprising the sequence of three six-membered rings of the 4H-benzo[h]chromene residue approximate a plane with the rms deviation of the fitted atoms being 0129 Å The bromobenzene ring forms a dihedral angle of 8534 (13)° with this plane, indicating an almost perpendicular relationship..

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Design, Synthesis, and Evaluation of Chromen-2-ones as ,

The discovery of a series of chromen-2-ones with selective affinity for the dopamine (DA) D4 receptor is described Target compounds were tested for binding to cloned human DA D2l, D3, and D42 receptor subtypes expressed in Chinese hamster ovary K1 cells Several compounds demonstrated high affinity (<20 nM, Ki) and greater than 100-fold selectivity for DA D42 versus DA D2l receptors The ...

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